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Matt Hancock has resigned as health secretary after he breached social distancing guidance by kissing a colleague.
In a letter to the PM he said the government “owe it to people who have sacrificed so much in this pandemic to be honest when we have let them down”.
In a video posted on Twitter, Mr Hancock said: “I have been to see the prime minister to resign as secretary of state for health and social care.
“I understand the enormous sacrifices that everybody in this country has made, that you have made, and those of us who make these rules have got to stick by them and that’s why I have got to resign.”
Boris Johnson said he was “sorry” to receive the resignation.
Former chancellor Sajid Javid has said he is “honoured” to have been chosen as Mr Hancock’s replacement. Mr Javid, who has held several key roles in government, said he was “honoured” to be appointed as health secretary “at this critical time”.
His return to cabinet comes 16 months after he resigned as chancellor when he rejected the prime minister’s order to fire his team of aides.
Before that Mr Javid was home secretary. He has also led the housing, communities, business and culture departments.
One of his first jobs as health secretary will be to examine the data ahead of England’s proposed end to Covid restrictions on 19 July.
Former health secretary Jeremy Hunt described Mr Javid’s appointment to the role as an “excellent choice”, saying it was the best possible news for social care because his time at the Department for Communities and Local Government meant he “gets it”.
However, Labour leader Sir Keir Starmer said Mr Johnson should have sacked Mr Hancock rather than wait for him to resign.
Matt Hancock has ended his 15-year marriage to his wife, Martha, and the relationship with Ms Coladangelo is understood to be a serious one.
Camera that Caught Hancock Kissing Gina Coladangelo Disabled
The camera that caught Matt Hancock kissing Gina Coladangelo has been disabled, new health secretary Sajid Javid says. Mr Javid said the device has been “disabled by the department”, adding that he does not believe ministers’ offices should have cameras fitted.
It comes as a cabinet office minister told MPs the camera in Mr Hancock’s office was an “outlier” and that it was not general policy for recording devices to be put in ministerial offices.
Asked about the device on Monday morning, Mr Javid said: “I haven’t disabled the camera that you are talking about, but it has been disabled by the department.
“I think for security it is just common sense… I don’t think, as a general rule, there should be cameras in the secretary of state’s office.
“I’ve never known that in the other five departments that I’ve run and I am not really sure why there was one here.
“But I am sure there will be more to this as the whole incident is investigated.”
Earlier on Monday, Justice Secretary Robert Buckland told Sky News he had asked for his office to be swept for “unauthorised devices” following the recording and leaking of footage of Matt Hancock from within the Department of Health and Social Care.
“I’ve never seen any camera facilities. I know there is CCTV in the building for obvious security reasons, but I am sure that many of my colleagues will be asking the same question and making sure that the offices are swept just in case there are unauthorised devices in there that could be a national security breach,” the justice secretary said.
“I think that is the sensible thing to do.”